Translational Science | Working Group

Working Group's Leads

To follow biologically informed plasma markers of disease through clinical time course of critical illness
To compare these markers between intervention groups
To predict outcomes using these markers of disease
To validate known disease associations in a novel population (critical illness)

Decentralized sample collection, with centralized sample storage
Centres categorized
1. Level 3 – Able to collect, process, and store samples for extended periods of time (archival storage)
  - Initially only TGH through TLTP biobank infrastructure
2. Level 2 – Able to collect, process, and store some samples for at least 2 weeks
3. Level 1 – Able to collect/process samples, but no -80 °C freezer access
  - Store limited samples for 48-72h
The PRACTICAL biobank will use the infrastructure of the TLTP biobank and will therefore use their data management system
Clinical data will be collected via the PRACTICAL case reporting form (CRF)