Translational Science

Working Group's Leads

Objectives

  • To follow biologically informed plasma markers of disease through clinical time course of critical illness
  • To compare these markers between intervention groups
  • To predict outcomes using these markers of disease 
  • To validate known disease associations in a novel population (critical illness)

Tasks

  • Decentralized sample collection, with centralized sample storage
  • Centres categorized
    1. Level 3 – Able to collect, process, and store samples for extended periods of time (archival storage)
      • Initially only TGH through TLTP biobank infrastructure
    2. Level 2 – Able to collect, process, and store some samples for at least 2 weeks
    3. Level 1 – Able to collect/process samples, but no -80 °C freezer access
      • Store limited samples for 48-72h
  • The PRACTICAL biobank will use the infrastructure of the TLTP biobank and will therefore use their data management system
  • Clinical data will be collected via the PRACTICAL case reporting form (CRF)

Group Members

image of Phyllis Billia

Dr. Phyllis Billia

MD, PhD, FRCPC, FACC

image of Alexandra Binnie

Dr. Alexandra Binnie

MD, DPhil, FRCPC

image of Bryan Coburn

Dr. Bryan Coburn

MD, PhD, FRCPC

image of Marcelo Cypel

Dr Marcelo Cypel

MD, MSc, FACS, FRCSC

image of Claudia Dos Santos

Dr. Claudia Dos Santos

M.Sc. MD. FRCPC

image of Shahid Husain

Dr. Shahid Husain

MD, MS, FECMM, FRCP(Edin)

image of Taylor Kain

Dr. Taylor Kain

MD, FRCPC

image of Patrick Lawler

Dr. Patrick Lawler

MD, MPH, FRCPC

Aleksandra Leligdowicz

MD, PhD, FRCPC

image of Braedon McDonald

Dr. Braedon McDonald

MD, PhD, FRCPC

image of Laveena Munshi

Dr. Laveena Munshi

MD, MSc, FRCPC

image of Arthur Slutsky

Dr. Arthur Slutsky

CM, FRSC, MASc, MD

image of Jennifer Tsang

Dr. Jennifer Tsang

MD, PhD, FRCPC, ABOM Diplomate

image of Brent Winston

Dr. Brent Winston

MD, FRCPC, FACP, FCCP, FCCM