Domains

Our domains test the effect of various interventional strategies on disease mechanisms and patient outcomes in patients requiring invasive or non-invasive respiratory support for acute hypoxemic respiratory failure.

Active

CORT-E2

Corticosteroid Early and Extended

The CORT-E2 pilot trial is to examine the role of corticosteroids in 1) early non-COVID acute respiratory failure and 2) non-resolving acute respiratory failure that has already been treated with a 10 day course of corticosteroids.

  • image of Bram Rochwerg
  • image of Lorenzo Del Sorbo
Active

ULTIMATE

Ultra-Low Tidal Volume Mechanical Ventilation in ARDS through ECMO

The ULTIMATE pilot trial is a multi-centre, randomized, open-label trial, embedded as a domain within the PRACTICAL platform trial.

  • image of Niall Ferguson
  • image of Eddy Fan
Active

PROACTIVE

Prevent Reduced Outcomes in ARDS by Transitioning from Invasive Ventilation to ECMO

The PROACTIVE pilot trial is a multi-centre, randomized, open-label trial, embedded as a domain within the PRACTICAL platform trial.

  • image of Eddy Fan
  • image of Aidan Burrell
  • image of Niall Ferguson
Active

IMV

Invasive Mechanical Ventilation Strategies

Interventions in this domain will be evaluated at various stages including pilot/feasibility evaluations, phase II, or phase III.

  • image of Ewan Goligher
  • image of Niall Ferguson
Active

CAPTIVATE

Consent for Adaptive Platform TrIals using abbreViATEd, patient-centered, modular audiovisual methods

CAPTIVATE is a study evaluating novel consent methods that is embedded within PRACTICAL and aims to innovate the conduct of informed consent methods within this trial, and inform the application of novel consent designs to future clinical trials.

  • image of Sylvain Lother
  • image of Lisa Burry
Active

FAST-3

Nebulized Furosemide for the Treatment of Pulmonary Inflammation in Patients with Respiratory Failure Secondary to Pulmonary Infection – A Phase 3 study

Nebulized furosemide, in addition to usual care will be evaluated as an adjunctive treatment in patients with hypoxemic respiratory failure requiring either invasive or non-invasive mechanical ventilation as to its efficacy for improvement of patient cente

  • image of John Muscedere
Active

FLUDRO

Fludrocortisone therapy in acute hypoxemic respiratory failure with airspace disease.

The FLUDRO-1 trial aims to gather direct evidence assessing the potential role of fludrocortisone combination therapy in the treatment acute hypoxemic respiratory failure (AHRF).

  • image of Bijan Teja
Active

IMV-ECLS

Mechanical Ventilation Strategies in Venovenous Extracorporeal Life Support (IMV-ECLS)

The Invasive Mechanical Ventilation Strategies in Venovenous-Extracorporeal Life Support (PRESSURE) is a pilot trial to identify PEEP strategies that improve lung function in AHRF patients on ECLS.

  • image of Lorenzo Del Sorbo
  • image of Ewan Goligher
  • image of Richard A. Greendyk